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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

A drug interaction trial with fluticasone propionate aqueous nasal spray in healthy subjects has shown that ritonavira strong CYP3A4 inhibitorcan significantly increase plasma fluticasone propionate exposureresulting in significantly reduced serum cortisol concentrationssee CLINICAL PHARMACOLOGYDuring postmarketing usethere have been reports of clinically significant drug interactions in patients receiving fluticasone propionate productsincluding FLONASEwith ritonavirresulting in systemic corticosteroid effects including Cushing’s syndrome and adrenal suppression.

Before using Flonase Nasal Spraytell your doctor if you have glaucoma or cataractsliver diseasediabetesherpes simplex virus of your eyestuberculosis or any other infectionsores or ulcers inside your noseor if you have recently had injury of or surgery on your nose.

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