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In postmenopausal womenestrogens can increase the risk of cancer of the ovariesstrokedementiaand serious blood clots in the legsEstrogens alone do not appear to increase the risk of breast cancer when used for up to 7 yearsEstrogenwhen used with a progestincan increase the risk of heart diseasesuch as heart attacksstrokeserious blood clots in the lungs/legsdementiaand cancer of the breast/ovaries.

Estrogen administration should be guided by clinical response rather than by hormone levelse.gestradiolFSH

Accelerated prothrombin timepartial thromboplastin timeand platelet aggregation timeincreased platelet countincreased factors IIVII antigenVIII antigenVIII coagulant activityIXXXIIVII-X complexII-VII-X complexand beta-thromboglobulindecreased levels of antifactor Xa and antithrombin IIIdecreased antithrombin III activityincreased levels of fibrinogen and fibrinogen activityincreased plasminogen antigen and activity.

This medication passes into breast milkIt may reduce the quality and amount of breast milk producedConsult your doctor before breast-feeding.

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