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Cymbaltaduloxetineis an antidepressant used for the treatment of fibromyalgiaFibromyalgia is a chronic disorder that causes widespread muscle pain and tendernesstrouble sleepingand overwhelming tiredness.

Duloxetine can pass into breast milkbut effects on the nursing baby are not knownTell your doctor if you are breast-feeding.

Changes in sexual desiresexual performance and sexual satisfaction often occur as manifestations of psychiatric disorders or diabetesbut they may also be a consequence of pharmacologic treatmentBecause adverse sexual reactions are presumed to be voluntarily underreportedthe Arizona Sexual Experience ScaleASEXa validated measure designed to identify sexual side effectswas used prospectively in 4 MDD placebo-controlled trialsIn these trialsas shown in Table 5 belowpatients treated with CYMBALTA experienced significantly more sexual dysfunctionas measured by the total score on the ASEXthan did patients treated with placeboGender analysis showed that this difference occurred only in malesMales treated with CYMBALTA experienced more difficulty with ability to reach orgasmASEX Item 4than males treated with placeboFemales did not experience more sexual dysfunction on CYMBALTA than on placebo as measured by ASEX total scoreNegative numbers signify an improvement from a baseline level of dysfunctionwhich is commonly seen in depressed patientsPhysicians should routinely inquire about possible sexual side effects.

Many drugs can interact with duloxetineNot all possible interactions are listed hereTell your doctor about all your current medicines and any you start or stop usingespecially:

You should not suddenly stop taking this medicineDoing so may cause unpleasant side effectsincluding nausea and headacheIf you wish or need to stop taking Cymbaltayour doctor will tell you how to reduce your dose gradually over time.

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certain drugs taken with cymbalta may increase or decrease the effect of the drug.

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