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Colchicine is contraindicated in patients with renal or hepatic impairment who are taking a P-gp inhibitore.gciclosporinverapamil or quinidineor a strong CYP3A4 inhibitore.gritonaviratazanavirindinavirclarithromycintelithromycinitraconazole or ketaconazolesee section 4.3

Published reports on the pharmacokinetics of intravenous colchicine in patients with severe chronic liver diseaseas well as those with alcoholic or primary biliary cirrhosisand normal renal function suggest wide inter-patient variabilityIn some subjects with mild to moderate cirrhosisthe clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjectsIn subjects with primary biliary cirrhosisno consistent trends were notedSee Hepatic ImpairmentNo pharmacokinetic data are available for patients with severe hepatic impairmentChild-Pugh C

Gout is rare in pediatric patientsthe safety and effectiveness of colchicine capsules in pediatric patients has not been evaluated in controlled studies.

Colchicine is used to prevent gout attackssuddensevere pain in one or more joints caused by abnormally high levels of a substance called uric acid in the bloodin adultsand to relieve the pain of gout attacks when they occurColchicine is also used to treat familial Mediterranean feverFMFan inborn condition that causes episodes of feverpainand swelling of the stomach arealungsand jointsin adults and children 4 years of age and olderColchicine is not a pain reliever and cannot be used to treat pain that is not caused by gout or FMFColchicine is in a class of medications called anti-gout agentsIt works by stopping the natural processes that cause swelling and other symptoms of gout and FMF.

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